Endocrine Abstracts

Background and Importance: Precocious puberty refers to sexual characteristics development before the normal age for its development. Neurofibromatosis Type 1 is an autosomal dominant condition with wide spectrum of clinical phenotype of which precocious puberty is common. This case report highlights the importance of recognizing this disease in patient presenting with precocious puberty and screening for optic pathway gliomas should be done and treat it to prevent the future ...

Objective: To study the spectrum of Pituitary tumours, their presentation, treatment and compliance with follow-up.Methods: A mixed retrospective and prospective study was conducted at the Medicell Institute of Diabetes, Endocrinology and Metabolism (MIDEM) and Jinnah Postgraduate Medical Centre (JPMC) Karachi, Pakistan. All cases of pituitary tumours, were prospectively followed. Data regarding age, gender, duration of disease, symptoms, mode of treatme...

Introduction: Adipokines, such as resistin and fasting-induced adipose factor (FIAF), are implicated in the regulation of insulin sensitivity and regulated by nuclear receptors like peroxisome proliferator activated receptor gamma (PPARγ), and retinoic acid receptor alpha (RARα). Primarily expressed in murine fat, we also showed that these adipokines are expressed in the mouse hypothalamus, as well as in N-1 hypothalamic neurons. We hypothesized that rosiglitazone (R...

Melanocortin receptor accessory protein (MRAP) is a single transmembrane domain protein, which has been identified as essential for the cell surface trafficking and signalling of the ACTH receptor (melanocortin 2 receptor (MC2R)). MRAP is essential for the function of MC2R, but regulation of its expression remains unclear. This study aims to identify factors regulating MRAP gene expression and whether these factors would affect the signalling of MC2R.The...

Background: Granulomatous mastitis (GM) is a rare inflammatory condition of the breast typically affecting women during postpartum period. GM can mimic inflammatory breast cancer and only be reliably distinguished through histopathology. While there is no generally accepted treatment for GM, therapeutic options include - antibiotics, wide surgical excision, and corticosteroids.Clinical Case: A 54-year-old female presented to her family physician with wit...

The optimum approach to long-term follow-up of well differentiated thyroid cancer (DTC) remains unclear. We assessed the outcome of DTC patients followed in primary care (PrC) from Edmonton, AB with tertiary care (TrC) settings from Halifax, NS and London, ON. Patients who met the following criteria were identified: a) Initial diagnosis between January 1, 2006 to December 31, 2011, b) primary tumourA total of 317 patients, (PrC=93 and TrC=2...

The optimum approach to long-term follow-up of well differentiated thyroid cancer (DTC) remains unclear. We assessed the outcome of DTC patients followed in primary care (PrC) from Edmonton, AB with tertiary care (TrC) settings from Halifax, NS and London, ON. Patients who met the following criteria were identified: a) Initial diagnosis between January 1, 2006 to December 31, 2011, b) primary tumourA total of 317 patients, (PrC=93 and TrC=2...

Objectives: The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly with obesity being a major risk factor. Adipocytes, besides storing fat, release a number of adipokines. Our study explored the association of leptin and resistin released by adipocytes in the pathogenesis of T2DM in context of metabolic syndrome.Methods: This was a cross sectional study in which we measured plasma levels of insulin, leptin and resistin in 50 healthy non-...

Introduction: Approximately 700 000 women give birth in England and Wales each year with up to 5% of these women having either pre-existing diabetes or gestational diabetes (GDM). Women who have diabetes during pregnancy, it is estimated that approximately 87% have GDM. It is well recognised that early diagnosis of diabetes aids in timely intervention to reduce long-term complications.Objectives: To assess the screening for diabetes mellitus in post-deli...

Introduction: Obstructive sleep apnoea (OSA) is common and frequently found in patients with obesity and type 2 diabetes mellitus. This case report shows the infrequently documented link between OSA and type 1 diabetes and highlights the need to confirm the type of diabetes especially in complex and atypical cases.Case report: A 44-year-old gentleman, with a BMI of 34, was diagnosed with type 2 diabetes and was treated with metformin and given lifestyle ...